What Rimetil Homocysteine 400 contains

In a single capsule, Rimetil Homocysteine 400 contains the active cofactors of the homocysteine cycle, designed to support both genetic hyperhomocysteinaemia related to MTHFR polymorphisms and acquired forms linked to diet, medication and oxidative stress.

• •5-MTHF – already active folate form, which does not require conversion from folic acid; particularly relevant in the presence of MTHFR variants.
• •Vitamin B12 as methylcobalamin – bioactive B12 form, directly used in the methionine and homocysteine cycle.
• •Vitamin B6 – essential cofactor in the trans-sulfuration pathway that converts homocysteine into cysteine.
• •Vitamin B2 – supports MTHFR enzyme function and folate recycling.
• •Anhydrous betaine – methyl donor for the conversion of homocysteine back into methionine.
• •Zinc – cofactor for several enzymes involved in methyl metabolism.

Methylcobalamin vs cyanocobalamin

Many homocysteine supplements have historically used cyanocobalamin, a synthetic form of B12 that the body must first convert into methylcobalamin and adenosylcobalamin. In people with genetic polymorphisms, toxic load or enzyme deficits, this conversion may be inefficient.

• •Methylcobalamin is already active and directly involved in the reaction that converts homocysteine into methionine.
• •Rimetil Homocysteine 400 has used methylcobalamin since its original formulation, not after later reformulations.
• •Many competitors, by contrast, switched to methylcobalamin only after recognising the functional limits of cyanocobalamin.

Who Rimetil Homocysteine 400 is designed for

Rimetil is designed whenever nutritional support for homocysteine metabolism and methylation is required. Its use should always be evaluated with a doctor, especially in sensitive areas such as cardiovascular prevention and pregnancy.

• •People with documented hyperhomocysteinaemia.
• •People with MTHFR polymorphisms and elevated homocysteine levels.
• •Men and women with cardiovascular risk factors where the doctor considers action on homocysteine metabolism appropriate.

Rimetil and pregnancy (always under medical supervision)

Homocysteine metabolism and folate status are particularly important before conception and during pregnancy. In these situations, the use of any supplement targeting homocysteine should always be evaluated and monitored by the gynaecologist or treating doctor.

• •Rimetil provides already active 5-MTHF folate and methylcobalamin, forms often preferred in the presence of MTHFR polymorphisms.
• •In preconception or pregnancy contexts, dose, duration and method of use must be established by the professional following the woman.

Directions for use

Unless otherwise indicated by your doctor, take 1 capsule in the morning with breakfast, with a little water.

Warnings

• •Keep out of reach of children under 3 years of age.
• •Do not exceed the recommended daily dose.
• •Food supplements should not be used as substitutes for a varied and balanced diet and a healthy lifestyle.
• •In case of pregnancy, breastfeeding, chronic conditions or ongoing drug therapy, consult your doctor before use.