Lactoferrin Plus 300 mg Shield
Lactoferrin is a key element to combat excessive inflammation and to modulate the host's immune response to protect against microbial and viral insults.
Lactoferrin (LF) was first identified as a milk protein by Sorensen in 1939 within cow's milk. Its presence in human Colostrum is abundant. Large-scale production of bovine LF (bLF) started more than 20 years ago. Using commercially available material, research has progressed from basic studies to clinical trials that have led to the use of bLF as a commercial dietary supplement over the past 25 years. During this period, it was found that LF is digested by gastric pepsin to generate a multi-potent peptide, lactoferricin. It has also been shown that oral administration of bLF increases host protection against infections through antimicrobial action and host immunomodulation. Furthermore, some research has shown that oral administration of bLF prevents the development of some types of cancer, although the scientific community has not definitively ruled in this regard. A very recent Italian research has proposed the use of lactoferrin also in inflammatory diseases of the respiratory and intestinal mucosa induced by some viruses.
Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that links innate and adaptive immune function in mammals.
Lactoferrin is a key element to combat excessive inflammation and to modulate the host's immune response to protect against microbial insults. Found in exocrine secretions, lactoferrin acts as a natural regulator of host defense. It is one of the first factors released by neutrophils when encountering pathogens and contributes to innate activation by directing the development of adaptive responses. Combined with its historical role in limiting microbial proliferation and functioning as a direct microbicidal agent, lactoferrin plays a central role in host immunity. Lactoferrin has the ability to modulate the production of cytokines by monocytes, as well as by lymphocytes, during activation by foreign or mitogenic stimuli. Furthermore, together with co-stimulatory mediators, lactoferrin can modulate the recognition of chemokines and the migratory potential of lymphocytes. This, coupled with the ability to influence the production and activity of reactive oxygen species, allows lactoferrin to act as a unique regulator for a wide range of responses, including those involved in septic shock (e.g. Systemic Inflammatory Response Syndrome. ), inflammation and subsequent development of disease-related pathologies. Bovine Lactoferrin (bLF), the main type of LF used in human medicine due to its easy availability, has been authorized by the American Food and Drug Administration and recognized as a safe food supplement (GRAS). Among the numerous protective activities exerted by this nutraceutical protein, the most important ones demonstrated by scientific research after its oral administration are: antianemic, anti-inflammatory, antimicrobial, immunomodulating, antioxidant and antitumor activity. All these activities underline the importance in the defense of the host of bLF, which represents an ideal nutraceutical product both for its economic production and for its tolerance after ingestion. It is right to reiterate that it is not a drug but a supplement that plays the role of adjuvant but never resolving on its own.
Lactoferrin Ketozona does not contain lactose, casein, sugars, magnesium stearate or other excipients and is in high dosages of 300 mg / capsule, ideal according to the most important scientific researches.
The use of lactoferrin should generally be contraindicated during pregnancy and in the subsequent breastfeeding period, given the absence of long-term studies on the safety profile of this molecule.
- Campione, E.; Cosio, T.; Rosa, L.; Lanna, C.; Di Girolamo, S.; Gaziano, R.; Valenti, P.; Bianchi, L. Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation. Int. J. Mol. Sci. 2020, 21, 4903.
- Superti F. Lactoferrin from Bovine Milk: A Protective Companion for Life. Nutrients. 2020;12(9):2562. Published 2020 Aug 24.
- Tomita, Mamoru & Wakabayashi, Hiroyuki & Shin, Kouichirou & Yamauchi, Koji & Yaeshima, Tomoko & Iwatsuki, Keiji. (2008). Twenty-Five years of research on bovine lactoferrin applications. Biochimie. 91. 52-7. 10.1016/j.biochi.2008.05.021.
- Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15(17):1956-1973.
- Kruzel ML, Actor JK, Boldogh I, Zimecki M. Lactoferrin in health and disease. Postepy Hig Med Dosw (Online) 2007;61:261–7
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